Always check the specific "Readme" file or release notes for the exact OS Build numbers (KB patches). Some Windows Updates released after the SP2 release may require a specific WinCC Update patch to maintain compatibility.
Siemens officially lists the following antivirus suites as compatible: wincc 7.5 sp2 compatibility list
WinCC V7.5 SP2 is officially supported on the following 64-bit platforms: : Professional and Enterprise. Windows 10 Enterprise LTSC : 2015, 2016, and 2019 versions. Always check the specific "Readme" file or release
Soft dongles (ALM) are difficult to manage in dynamic VMs. Siemens recommends using a or Static license file (SLS) . wincc 7.5 sp2 compatibility list