For a general overview of common errors and troubleshooting steps within TWiLight Menu++: López Tutoriales YouTube• Apr 16, 2021 is known to cause this error?
DeSmuME has an option to run games in "DSi Mode." If you toggle this setting on but feed the emulator a standard Nintendo DS ROM (not a DSi ROM), the emulator looks for binaries that are not there, and throws this error. The Dsi Binaries Are Missing Please Obtain A Clean Rom