If you prefer not to use mods, you can mitigate some input lag with these steps:
Extract dinput8.dll and dinput8.ini into your game's Bin32 folder. Original 2007 PC Port (Ubisoft/Sourcenext) Download Resident Evil 4 Pc Mouse Support
Depending on whether you are playing the Resident Evil 4 (2005) classic or the 2023 Remake If you prefer not to use mods, you